New tech for controlling genetic inheritance and genome engineering

Science Daily | Feb. 6, 2018

Now, Shannon Xu, together with Gantz and Bier, employ CRISPR/Cas9 to edit gene regulatory elements in their native genomic environments, revealing new fundamental mechanisms that control gene activity, as described Feb. 6 in eLife. The authors also provide experimental validation for using active genetics as an efficient means for targeted gene insertion, or “transgenesis,” and single-step replacement of genetic control elements.

“Technical advances enabled by active genetics represent an innovative toolkit to engineer organisms with novel features, thereby enabling a new era of advances in synthetic biology,” said Gantz.

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